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Professor Tom Shemesh

Tom Shemesh教授

Faculty of Biology, Technion - Israel Institute of TechnologyTom 以色列理工学院生物学院

Prof. Shemesh's group construct theoretical, physics-based models for the formation, shaping and function of sub-cellular structures. Primarily, we study the morphology of membrane surfaces in the endoplasmic reticulum (ER); and self-arrangement and force production in the actin cytoskeleton. The research in his lab is inherently interdisciplinary: we use physics considerations and computer simulations while working in close collaboration with experimental biologists in an effort to create models that are relevant to understanding the actual biological systems. In contrast with information-focused theoretical biology, we study the “blue collar”, mechanical, role of proteins and lipids.

Tom Shemesh教授为亚细胞结构的形成、构型和功能构建了基于物理学的理论模型。通过他的模型,我们主要能得知内质网膜表面的形态学以及肌动蛋白细胞骨架中的自我排列和力生成。他的实验室的研究本质上是跨学科的:“我们在与实验生物学家密切合作的过程中,利用物理学的观点和计算机模拟,试图创造能够理解真实生物系统的模型。不同于以信息为中心的理论生物学,我们研究的是蛋白质、脂类的‘蓝领(体力劳动的)’、机械性的作用。”

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